[N A J Med Sci. 2012;5(2):71-77.] PDF File
Chiung-Min Wang, BS; Wei-Hsiung Yang, PhD*
Post-translational modifications to proteins are essential mechanisms for controlling functions of proteins and subsequently for regulating cell fate. SUMO modification (SUMOylation) has emerged as a critical regulatory pathway in cellular function and biological processes. DeSUMOylation (removal of SUMO conjugation) by members of SUMO-specific proteases (SENPs) family makes SUMO modification highly dynamic. In this mini-review, we briefly introduce the current knowledge regarding the regulatory pathway of deSUMOylation and focus on the recent progress of functions of SENPs in biological progresses.
Key Words: SUMO, deSUMOylation, SENP SUMO, deSUMOylation, SENP
Department of Biomedical Sciences, Mercer University School of Medicine, Savannah, GA 31404, USA
*Corresponding Author: Department of Biomedical Sciences, Mercer University School of Medicine, 4700 Waters Ave, Savannah, GA 31404. Tel: 912-350-1708. Fax: 912-350-1765. (Email: firstname.lastname@example.org)