Recent Progress of DeSUMOylation in Biological Processes: A Mini Review [Abstract]

April 25, 2012

[N A J Med Sci. 2012;5(2):71-77.] PDF File

Chiung-Min Wang, BS; Wei-Hsiung Yang, PhD*

Post-translational modifications to proteins  are essential mechanisms for controlling functions of proteins and subsequently for regulating  cell fate. SUMO modification (SUMOylation) has emerged as a critical regulatory pathway in  cellular function and biological processes. DeSUMOylation (removal of SUMO conjugation) by  members of SUMO-specific proteases (SENPs) family makes SUMO modification highly dynamic.  In this mini-review, we briefly introduce the current knowledge regarding the regulatory  pathway of deSUMOylation and focus on the recent progress of functions of SENPs in biological  progresses. 

Key Words: SUMO, deSUMOylation, SENP SUMO, deSUMOylation, SENP

Go To: | Top | Abstract | Text | Author Information | References |

_____________________________________________________________________________________

Chiung-Min Wang, BS; Wei-Hsiung Yang, PhD* 

Department  of Biomedical Sciences, Mercer University School of Medicine, Savannah, GA 31404,  USA 

*Corresponding Author: Department  of Biomedical Sciences, Mercer University School of Medicine, 4700 Waters Ave, Savannah,  GA 31404. Tel: 912-350-1708. Fax: 912-350-1765. (Email: yang_w@mercer.edu) 

5 stat all 1 stat today

Comments are closed.