Elastotic Changes in the Gastrointestinal Tract: A Review of Literature [Abstract]

April 25, 2012

[N A J Med Sci. 2012;5(2):78-81.] PDF File

Ines Krammer, MD;* Hallie Kretsinger; Bruno Märkl, MD

 Elastotic changes are benign lesions in the gastrointestinal  tract that often appear as polyps and show histologically a remarkable increase in elastic  fibers. Because of their hyaline and amorphous appearance in hematoxylin and eosin (H&E) stained  slides, elastotic changes often resemble amyloidosis. However, they are negative in Congo  red staining. Reviewing the literature we found 35 cases in 12 publications in the English  and French literature since 1985. The results indicate that the patients’ age ranged from  24 to 88 years (mean 58.2, median 58) and presented a balanced gender ratio (M/F = 17/18).  Usually the lesions presented as polyps or irregular mucosal areas. Mostly, they were found  during endoscopic examination in the colon or rectum (16 cases), while six cases were located  in the stomach and only two in the small bowel. Some authors consider the alterations to be  a reactive process, e.g. within (gastric) ulcers, whereas others speculate about a connection  with systemic diseases of the connective tissue (Ehlers-Danlos Syndrome, Pseudoxanthoma elasticum).  Based on our observations we distinguished angioelastosis, showing a relation to submucosal  vessels, as a separate entity from gastrointestinal elastofibroma, that presents the same  histologic morphology as Elastofibroma dorsi. Conclusion: Elastofibromatous changes in the  gastrointestinal tract are quite common benign findings and should be considered as a possible  differential diagnosis in examining gastrointestinal specimens. 

Key Words: gastrointestinal tract, polyps, elastosis, angioelastosis, elastofibroma gastrointestinal tract, polyps, elastosis, angioelastosis, elastofibroma

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Ines Krammer, MD;* Hallie Kretsinger; Bruno Märkl,  MD

Institute  of Pathology, Klinikum Augsburg, Augsburg, Germany 

*Corresponding Author: Institute  of Pathology, Klinikum Augsburg, Stenglinstrasse 2, 86156 Augsburg, Tel: +49 821 400 2150,  FAX: +49 821 400 2162. (Email: Ines.Krammer@klinikum-augsburg.de) 

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